When AI decodes life’s biggest mysteries

12

October

2019

5/5 (1)

Go, a very strategic board game that originated over 3000 years ago in China, is known as one of the most challenging classical games for artificial intelligence (AI) (DeepMind, n.d.). Still, in 2015 an algorithm called AlphaGo was released by the company DeepMind and has since beat professional Go players and world champions on a consistent basis (DeepMind, n.d.a). Today, AlphaGo is considered an AI breakthrough and the strongest Go player in the world (DeepMind, n.d.; Meyer, 2017).

The company behind AlphaGo, DeepMind, is an AI R&D company that was acquired by Google in 2014 (DeepMind, n.d.b). While many might have heard of DeepMind and AlphaGo before, fewer people have heard of AlphaFold. AlphaFold is another algorithm developed by DeepMind that was presented to the public at the end of 2018 (DeepMind, n.d.c). Some say that AlphaFold is DeepMind’s biggest strike yet and could have a strong impact on our lives in the future (Zonnev, 2019). It is an algorithm that predicts a protein’s 3D structure based on its genetic sequence (DeepMind, n.d.c). So far, scientists have spent a lot of time understanding our DNA, but still struggle with a basic question in protein folding: how does a protein must be folded, so that it will work in the way it is supposed to (Zonnev, 2018)? If scientists could learn the process of protein folding better, they can find out exactly what a protein does and how it might cause harm (Sample, 2018). This could help in designing new proteins to fight diseases or help with other tasks, such as breaking down plastic in the environment (Sample, 2018).

DeepMind’s AlphaFold has participated in the CASP competition last year, which is a scientific competition where they test people’s ability to model proteins (Koonce, 2019). AlphaFold won first place and was able to correctly predict the folding of proteins 25 out of 43 times, while the second place only predicted 3 correct (Wiggers, 2018). Nevertheless, there are still some people who argue that AlphaFold’s algorithm is not as much of a breakthrough yet (see for example Al Quraishi, 2018; Service, 2018).

In conclusion, protein folding is a very complex topic and I need to understand it better first in order to grasp the implications of AlphaFold. Nonetheless, I personally find it very interesting when AIs enter the space of biology and could help us in solving some of life’s biggest mysteries that could significantly improve our lives in the future.

 

References

Al Quraishi, M. (2018). AlphaFold @ CASP13: “What just happened?”. Retrieved from https://moalquraishi.wordpress.com/2018/12/09/alphafold-casp13-what-just-happened/

DeepMind. (n.d.a). AlphaGo. Retrieved from https://deepmind.com/research/case-studies/alphago-the-story-so-far

DeepMind. (n.d.b). About. Retrieved from https://deepmind.com/about

DeepMind. (n.d.c). AlphaFold: Using AI for scientific discovery. Retrieved from https://deepmind.com/blog/article/alphafold

Koonce, B. (2019). An Introduction to AlphaFold and Protein Modeling. Retrieved from https://medium.com/quark-works/an-introduction-to-alphafold-and-protein-modeling-b83edadcff2b

Meyer, D. (2017). Google’s New AlphaGo Breakthrough Could Take Algorithms Where No Humans Have Gone. Retrieved from https://fortune.com/2017/10/19/google-alphago-zero-deepmind-artificial-intelligence/

Sample, I. (2018). Google’s DeepMind predicts 3D shapes of proteins. Retrieved from https://www.theguardian.com/science/2018/dec/02/google-deepminds-ai-program-alphafold-predicts-3d-shapes-of-proteins

Service, F., R. (2018). Google’s DeepMind aces protein folding. Retrieved from https://www.sciencemag.org/news/2018/12/google-s-deepmind-aces-protein-folding

Wiggers, K. (2018). Deepmind’s AlphaFold wins CASP13 protein-folding competition. Retrieved from https://venturebeat.com/2018/12/03/deepminds-alphafold-wins-casp13-protein-folding-competition/

Zonnev, C. (2019). How Google Is Decoding Nature’s Formula Of Life — Using AI — This is Their Biggest Strike Yet. Retrieved from https://towardsdatascience.com/https-medium-com-decoding-natures-formula-of-life-using-ai-this-is-google-deepmind-biggest-strike-yet-2da4a5992729

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A.I in health-care: The new application of DeepMind called ‘Streams’

12

September

2017

4.5/5 (6)

What is DeepMind? DeepMind is an Artificial Intelligence (AI) company founded in 2010 in the U.K. DeepMind was acquired by Google in 2014. The majority of readers know DeepMind from the famous AlphaGo program that beat the world’s best Go player for the first time. However, DeepMind is said to be also currently working on health-care focused projects that can help in detecting and diagnosing diseases in the early stages.

‘DeepMind and Streams’

DeepMind has developed an application called ‘Streams’, which is aimed at solving the problem of “failure to rescue” where the right health-care professionals do not succeed in treating the patient in time. Streams aims to solve this problem, by providing a system which can immediately process test results. In the case that an issue is found, a notification is sent to alert the health-care professional to help, together with further information regarding the patient. Streams does this by using different types of data and test results from existing IT systems in the respective hospital. Streams has witnessed a lot of success, as nurses say it saves them up to ‘two hours a day’, and patients claiming to have been attended to faster.

deepmind streams

 

‘Streams and Sensitive Data’

However, Google/DeepMind has been under a lot of scrutiny due to Streams. Powles & Hodson (2017) imply that sensitive medical information has been mishandled. As mentioned earlier, Streams relies on existing information from patients to make early diagnoses. However, Streams has access to 1.6 million medical records, and this information was delivered by the National Health Service (NHS) in the U.K. through a data-sharing agreement signed in 2015. Within these medical records lie data that is irrelevant to some of Streams’ services, but critical to patients’ privacy. Therefore, some claim that access to unnecessary data should be restricted.

We know that data plays an important role in the development of A.I such as DeepMind (Machine Learning). But to what extent can A.I be implemented in health-care? How can sensitive data regarding patient’s medical records be properly handled and analyzed? Will we see more A.I in healthcare in the future, and what kind?

 

Sources:
https://www.forbes.com/sites/bernardmarr/2017/08/08/the-amazing-ways-how-google-uses-deep-learning-ai/2/#50020b4d35e4
https://deepmind.com/applied/deepmind-health/about-deepmind-health/
https://www.theverge.com/2017/3/16/14932764/deepmind-google-uk-nhs-health-data-analysis
Powles, J., & Hodson, H. (2017). Google DeepMind and healthcare in an age of algorithms. Health and Technology, 1-17.

 

Deniz Ozer

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Welcome to the Future: Google DeepMind’s Artificial Intelligence Algorithm

21

September

2016

5/5 (16)

In March 2016, something historical happened, something scientists did not expect to happen for at least another decade. An Artificial Intelligence (A.I.) algorithm named AlphaGO beat the current world champion Lee Sedol at the GO board game.  Now, in order to clarify why this indeed has historical consequences, some background information is required. First, some information about the ancient Chinese board game GO: GO is known as the world’s hardest game with close to an infinite number of optional plays. The game is comparable to chess, only with more moves than there are atoms in the entire universe.

Given the amount of options the game GO has, it was not possible for the algorithm to win by ‘brute forcing’. Previously, when computer systems played other games (e.g. chess) brute forcing was used in order to make in-game decisions. Simply said, brute forcing means that an algorithm would calculate all moves it could possibly make and select the most ‘successful’ move. Because brute forcing is not possible with GO, this ancient Chinese game is seen as the Holy Grail (i.e. test) of Artificial Intelligence. As brute forcing was not an option, Google DeepMind’s AlphaGO used a different technique in order to win. And this is where things get spectacular.

For the first time in history, we are seeing a successful demonstration of general purpose Artificial Intelligence. What does general purpose mean in this case? Because the machine learns from experience and data, it can perform well through a wide variety of tasks. Not only within one specific area.
By using reinforced learning and neural networks AlphaGO could mimic the learning process of a human brain. Meaning: it shows that machines have the potential to learn on their own.
AlphaGO’s win over a human with the game GO shows that machines can really learn and think in a human way. According to the DeepMind founders, the algorithm can learn many more things besides GO. Without alteration or guidance by human hand. In other words, AlphaGO can indeed be defined as general purpose A.I.

Google DeepMind, the company responsible for the creation of AlphaGO, is a British Artificial Intelligence company that was founded in September 2010 as DeepMind technologies. It was renamed into Google DeepMind after it was acquired by Google for a shy $500 million. Fun fact: Next to Google’s interest in the company, other well established names are connected with DeepMind. For example, Elon Musk is one of the investors behind the DeepMind company.
The company goal of DeepMind is ‘to solve intelligence’. The team is trying to achieve this by combining the best techniques from machine learning and systems neuroscience, in order to build powerful general purpose algorithms.  Summarized, the goal of Google DeepMind is to formalize intelligence, find out what it is, and how it works. The end game is not just to implement this into machines, but also to understand the human brain.

Back to the AlphaGO algorithm. So far, we have established that it can be defined as a general purpose A.I. with the potential to learn on its own.
But how does the program learn? Through Deep Reinforcement Learning.  Which again makes it very different from other A.I.’s. Other current A.I.’s were only developed for a predefined purpose and only function within their scope (e.g. Siri on your new iPhone 7). DeepMind claims that their algorithm is not pre-programmed and learns from experience. Using only raw pixels as data input.
Reinforcement learning can be seen as the foundation for the program’s win over the current world champion. AlphaGO was trained by showing the programme over 100.000 pictures of amateurs playing GO. Its first task was to mimic these pictures. After it learned to mimic human amateurs their plays, the algorithm was allowed to play against itself. 13 million times to be exact.
Using deep reinforcement learning, the system learns to improve itself incrementally by increasing its win-rate against older versions of itself. The reinforcement system DeepMind uses, is model free. Meaning that it doesn’t need a structure or a set of rules to learn.

Where can DeepMind’s algorithm be used for in the future? In an interview with one of the founders, Mustafa Suleyman, he explains their vision of applying A.I. in healthcare and science. He mentions it will help speed up the process of major breakthroughs by helping human experts discover patterns.

Concluding, general purpose artificial intelligence that uses reinforcement learning could lay the groundwork for unimaginable things in the near future.

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